SnapShot: Centriole Biogenesis
نویسندگان
چکیده
an d d up lic at io n SPD2 (Ce, Dm)/ CEP192 (Hs) No centriole duplication (Ce); <PCM recruited (Ce, Dm, and Hs); no basal body duplication (Dm) Asterless (Dm)/ CEP152 (Dr, Hs) Aberrant PCM recruitment (Dm) and centriole duplication (Dm and Dr) γ-Tubulin (Dm, Hs, Tt, Pt)/TBG (Ce) Aberrant centriole duplication (Ce, Hs, Tt), centriole structure and separation (Pt, Dm) Overexpression: de novo formation, amplifi cation of basal bodies (Tt)
منابع مشابه
Deuterosome-mediated centriole biogenesis.
The ability of cells to faithfully duplicate their two centrioles once per cell cycle is critical for proper mitotic progression and chromosome segregation. Multiciliated cells represent an interesting variation of centriole duplication in that these cells generate greater than 100 centrioles, which form the basal bodies of their motile cilia. This centriole amplification is proposed to require...
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Centrioles are essential for the assembly of both centrosomes and cilia. Centriole biogenesis occurs once and only once per cell cycle and is temporally coordinated with cell-cycle progression, ensuring the formation of the right number of centrioles at the right time. The formation of new daughter centrioles is guided by a pre-existing, mother centriole. The proximity between mother and daught...
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Centrioles duplicate once in each cell division cycle through so-called templated or canonical duplication. SAK, also called PLK4 (SAK/PLK4), a kinase implicated in tumor development, is an upstream regulator of canonical biogenesis necessary for centriole formation. We found that overexpression of SAK/PLK4 could induce amplification of centrioles in Drosophila embryos and their de novo formati...
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Cilia formation is a multi-step process that starts with the docking of a vesicle at the distal part of the mother centriole. This step marks the conversion of the mother centriole into the basal body, from which axonemal microtubules extend to form the ciliary compartment. How vesicles are stably attached to the mother centriole to initiate ciliary membrane biogenesis is unknown. Here, we inve...
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Supernumerary centrosomes are a key cause of genomic instability in cancer cells. New centrioles can be generated by duplication with a mother centriole as a platform or, in the absence of preexisting centrioles, by formation de novo. Polo-like kinase 4 (Plk4) regulates both modes of centriole biogenesis, and Plk4 deregulation has been linked to tumor development. We show that Plx4, the Xenopus...
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ورودعنوان ژورنال:
- Cell
دوره 136 شماره
صفحات -
تاریخ انتشار 2009